Shiyu Chen, Ph.D.

Postdoctoral Fellow
Department of Pathology
School of Medicine
Stanford University, USA

Mail address:

Edwards Bld. Rm R-317
300 Pasteur Drive
Stanford, CA 94305-5324, USA

Contact:

Tel: +1 (650) 736-4099
Fax: +1 (650) 725-7424
E-mail: shiyu@stanford.edu

Education & Training

2015–Now
Postdoc

Stanford University, USA
School of Medicine
Department of Pathology
Group of Prof. Matthew Bogyo (mbogyo@stanford.edu)

2009–2014
Ph.D. degree

Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Institute of Chemical Sciences and Engineering (ISIC)
Laboratory of Therapeutic Peptides and Proteins (LPPT)
Supervisor: Prof. Christian Heinis (christian.heinis@epfl.ch)

2005–2008
M.S. degree

Major in Medicinal Chemistry
Chinese Academy of Sciences (CAS), Shanghai, China
Shanghai Institute of Materia Medica (SIMM)
Supervisor: Prof. Hong Liu (hliu@mail.shcnc.ac.cn)

2001–2005
B.S. degree

Study in Chemistry, Major in Analytical Chemistry
Department of Chemistry, Nanjing University, China
Supervisor: Prof. Jianxin Li (lijxnju@nju.edu.cn)

Publications
13) V. Baeriswyl, S. Calzavarini, S. Chen, A. Zorzi, L. Bologna, A. Angelillo-Scherrer and C. Heinis, A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation, ACS Chem Biol. 2015, 10, 1861-1870. [fulltext]
12) S. Chen, R. Gopalakrishnan, T. Schaer, F. Marger, R. Hovius, D. Bertrand, F. Pojer, C. Heinis, Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nat. Chem. 2014, 6, 1009–1016. [fulltext]
11) S. Bellotto, S. Chen, I. Rentero-Rebollo, H. Wegner, C. Heinis, Phage selection of photoswitchable peptide ligands, J. Am. Chem. Soc. 2014, 136, 5880-5883. [fulltext]
10) S. Chen, D. Bertoldo, A. Angelini, F. Pojer, C. Heinis, Peptide ligands stabilized by small molecules, Angew. Chem., Int. Ed. 2014, 53, 1602-1606. [fulltext]
9) S. Chen, I. Rentero Rebollo, S. A. Buth, J. Morales-Sanfrutos, J. Touati, P. G. Leiman, C. Heinis, Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries, J. Am. Chem. Soc. 2013, 135, 6562-6569. [fulltext]
8) S. Chen, J. Touati, C. Heinis, Tracking chemical reactions on the surface of filamentous phage using mass spectrometry, Chem. Commun. (Camb) 2013, 50, 5267-5269. [fulltext]
7) S. Chen, D. Gfeller, S. A. Buth, O. Michielin, P. G. Leiman, C. Heinis, Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids, ChemBioChem 2013, 14, 1316-1322. [fulltext]
6) B. Lee, S. Chen, C. Heinis, R. Scopelliti, K. Severin, Pattern-based sensing of peptides and aminoglycosides with a single molecular probe, Org. Lett. 2013, 15, 3456-3459. [fulltext]
5) S. Chen, J. Morales-Sanfrutos, A. Angelini, B. Cutting, C. Heinis, Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides, ChemBioChem 2012, 13, 1032-1038. [fulltext]
4) V. Baeriswyl, H. Rapley, L. Pollaro, C. Stace, D. Teufel, E. Walker, S. Chen, G. Winter, J. Tite, C. Heinis, Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases, ChemMedChem 2012, 7, 1173-1176. [fulltext]
3)   A. Angelini, J. Morales-Sanfrutos, P. Diderich, S. Chen, C. Heinis, Bicyclization and tethering to albumin yields long-acting peptide antagonists, J. Med. Chem. 2012, 55, 10187-10197. [fulltext]
2) A. Angelini, L. Cendron, S. Chen, J. Touati, G. Winter, G. Zanotti, C. Heinis, Bicyclic peptide inhibitor reveals large contact interface with a protease target, ACS Chem. Biol. 2012, 7, 817-821. [fulltext]
1) S. Chen, H. Huang, X. Liu, J. Shen, H. Jiang, H. Liu, Microwave-assisted efficient copper-promoted N-arylation of amines with arylboronic acids, J. Comb. Chem. 2008, 10, 358-360. [fulltext]

Patents
1) Polycyclic peptides based on di-thiol amino acids. C. Heinis, S. Chen, R. Gopalakrishnan.

Book Chapters
2) S. Chen, C. Heinis, in Biotherapeutics: Recent Developments using Chemical and Molecular Biology, CHAPTER 9 Phage Selection of Mono- and Bicyclic Peptide Ligands, The Royal Society of Chemistry, 2013, pp. 241-262. [fulltext]
1) S. Chen, C. Heinis, in Methods in Molecular Biology, Phage Selection of Bi-cyclic Peptides Based on Two Disulfide Bridges, Submitted.