Shiyu Chen, Ph.D. |
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Postdoctoral Fellow |
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Mail address: |
Edwards Bld. Rm R-317 |
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Contact: |
Tel: +1 (650) 736-4099 |
Education & Training |
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2015–Now |
Stanford University, USA |
2009–2014 |
Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland |
2005–2008 |
Major in Medicinal Chemistry |
2001–2005 |
Study in Chemistry, Major in Analytical Chemistry |
Publications |
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13) | V. Baeriswyl, S. Calzavarini, S. Chen, A. Zorzi, L. Bologna, A. Angelillo-Scherrer and C. Heinis, A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation, ACS Chem Biol. 2015, 10, 1861-1870. [fulltext] |
12) | S. Chen, R. Gopalakrishnan, T. Schaer, F. Marger, R. Hovius, D. Bertrand, F. Pojer, C. Heinis, Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nat. Chem. 2014, 6, 1009–1016. [fulltext] |
11) | S. Bellotto, S. Chen, I. Rentero-Rebollo, H. Wegner, C. Heinis, Phage selection of photoswitchable peptide ligands, J. Am. Chem. Soc. 2014, 136, 5880-5883. [fulltext] |
10) | S. Chen, D. Bertoldo, A. Angelini, F. Pojer, C. Heinis, Peptide ligands stabilized by small molecules, Angew. Chem., Int. Ed. 2014, 53, 1602-1606. [fulltext] |
9) | S. Chen, I. Rentero Rebollo, S. A. Buth, J. Morales-Sanfrutos, J. Touati, P. G. Leiman, C. Heinis, Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries, J. Am. Chem. Soc. 2013, 135, 6562-6569. [fulltext] |
8) | S. Chen, J. Touati, C. Heinis, Tracking chemical reactions on the surface of filamentous phage using mass spectrometry, Chem. Commun. (Camb) 2013, 50, 5267-5269. [fulltext] |
7) | S. Chen, D. Gfeller, S. A. Buth, O. Michielin, P. G. Leiman, C. Heinis, Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids, ChemBioChem 2013, 14, 1316-1322. [fulltext] |
6) | B. Lee, S. Chen, C. Heinis, R. Scopelliti, K. Severin, Pattern-based sensing of peptides and aminoglycosides with a single molecular probe, Org. Lett. 2013, 15, 3456-3459. [fulltext] |
5) | S. Chen, J. Morales-Sanfrutos, A. Angelini, B. Cutting, C. Heinis, Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides, ChemBioChem 2012, 13, 1032-1038. [fulltext] |
4) | V. Baeriswyl, H. Rapley, L. Pollaro, C. Stace, D. Teufel, E. Walker, S. Chen, G. Winter, J. Tite, C. Heinis, Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases, ChemMedChem 2012, 7, 1173-1176. [fulltext] |
3) | A. Angelini, J. Morales-Sanfrutos, P. Diderich, S. Chen, C. Heinis, Bicyclization and tethering to albumin yields long-acting peptide antagonists, J. Med. Chem. 2012, 55, 10187-10197. [fulltext] |
2) | A. Angelini, L. Cendron, S. Chen, J. Touati, G. Winter, G. Zanotti, C. Heinis, Bicyclic peptide inhibitor reveals large contact interface with a protease target, ACS Chem. Biol. 2012, 7, 817-821. [fulltext] |
1) | S. Chen, H. Huang, X. Liu, J. Shen, H. Jiang, H. Liu, Microwave-assisted efficient copper-promoted N-arylation of amines with arylboronic acids, J. Comb. Chem. 2008, 10, 358-360. [fulltext] |
Patents |
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1) | Polycyclic peptides based on di-thiol amino acids. C. Heinis, S. Chen, R. Gopalakrishnan. |
Book Chapters |
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2) | S. Chen, C. Heinis, in Biotherapeutics: Recent Developments using Chemical and Molecular Biology, CHAPTER 9 Phage Selection of Mono- and Bicyclic Peptide Ligands, The Royal Society of Chemistry, 2013, pp. 241-262. [fulltext] |
1) | S. Chen, C. Heinis, in Methods in Molecular Biology, Phage Selection of Bi-cyclic Peptides Based on Two Disulfide Bridges, Submitted. |